Effector functions of matched sets of recombinant human IgG subclass antibodies

Contents

• Introduction
• Effector functions of anti-NP antibodies
• Effector functions of IgG antibodies to the CAMPATH-1 (CD52) antigen
• Functional epitopes of human IgG1 and IgG4
• Immunoglobulin allotypes
• Animal Models
• Conclusions
• Figures
  • Figure 1. Effector functions of anti-NP chimaeric antibodies.
  • Figure 2. Effector functions of CAMPATH-1 (CD52) chimaeric antibodies.
  • Figure 3. Identification of functional features of IgG by domain swapping.
  • Figure 4. IgG1 allotypes.
  • Figure 5. Comparison of IgG1 allotypes.
• References
• Acknowledgement of source material.

Extra Information

Since this article was originally written the development of the CAMPATH-1 antibodies has continued but no longer as a product from Glaxo-Wellcome. For more information see the web pages for the Therapeutic Antibody Centre in Oxford.

I have also completed a more recent review of IgG structure which extends the work described here. See Clark, M (1997), Chemical Immunology 65, 88-110 Antibody Engineering IgG Effector Mechanisms. In addition there is some more online information on this topic including a useful figure marking up the residues referred to in the text of this article.

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