These webpages on immunoglobulin structure and function have been prepared by Mike Clark, PhD, Cambridge University, Cambridge UK. The pages here stem from my own academic teaching and research interests in immunoglobulin structure and function. My intention is to continue to develop them as a resource not only for my own use but also as a reference source for students and researchers with a similar interest in immunoglobulins. However you should be aware that I exercise my rights to copyright over the material that I have produced.
If you have suggestions for additions, changes or corrections to any of my material then please email me. I am also eager to hear from anyone who has web material of relevance which they would like me to cross-reference from here.
What no frames? (A policy statement).
The following links refer to my own online resources provided by me from servers in Cambridge University , Cambridge UK. Their content is copyright © Mike Clark, Cambridge University.
Images of Immunoglobulin Molecules.
I created these images for use in my undergraduate teaching.
Mouse IgG2a
A structure of a complete IgG antibody.
Some models of human IgG1.
Illustrating differences in human IgG isotype and allotype.
IgG functions.
Functional sites on the IgG molecule (complement and Fc receptor).
IgG functions.
A review article transformed for online viewing.
About the Immunoglobulin Images
For a brief description of how I created these pages and images.
Mike's Animated molecules.
I have made some animations from the model structures.
Some molecular model files to download.
Some of the model structures are provided in PDB format for use with
suitable viewing applications.
Mike's talk at the BSI meeting, Birmingham, March 95.
This discusses differences in function with Ig isotypes and allotypes.
An account of a BSI exchange visit to Moscow
in December 1997
25 years of monoclonal antibodies.
To celebrate the 25th anniversary of monoclonal antibodies in 2000 and the controversy surrounding the failure to
patent monoclonal antibodies.
Mike's Patent Filings.
Patents, a necessary evil? A Listing of Mike Clark's Patent filings and a
commentary
Humanising
or reshaping antibodies for therapeutic use (Review Article).
Humanisation
A discussion of Chimaeric, Humanised and Fully Human Antibodies
TAHHP
The Therapeutic Antibody Human Homology Project.
CAMPATH-1H
A personal account of the humanisation of this therapeutic antibody.
Please remember to book-mark this page before leaving for another site!
Over the years this website has received a number of awards and accolades from sites several of which don't seem to have lasted as well as my own! I have kept the badges for posterity below, but I have converted the broken URLs into invisible comments in the html.
About Mike Clark.
My work, interests, hobbies and some opinions!
For a listing of Mike Clark's publications.
Mike's opinions on The Lancet GM food debate
These web pages are meant as an academic resource and as such I would like them to remain accessible and useful to the widest number of individuals. I have therefor deliberately avoided the current trend to introduce a whole host of unique and non-standard features which require specific web browsers to be used to access the pages. So until features such as frames are written into the HTML standards I am deliberately avoiding their use on this website. Hopefully users will agree that what is important is the information provided within the site rather than a specific mode of presentation.
However if you seem to be viewing this site in a frame surrounded by advertisements and other navigation aids you might like to visit this link to a further policy statement of mine.
Mike Clark
A large selection of selected links to immunoglobulin resources.
Email
Postal address
Telephone and facsimile